Research
Research Interest
Our lab focuses on conducting investigations in these four areas:
Study of Mobile Elements and Retrocopies
We are dedicated to uncovering the roles and mechanisms of Mobile Elements (MEs) and retrocopies within the genome. Our research is crucial for understanding genomic variability and its implications for evolution and disease, particularly in the context of cancer genomics. Specifically, our investigations focus on the formation, evolution, and functional roles of mRNA retrocopies (processed pseudogenes). We are particularly interested in how retrocopies can mimic gene function and influence gene regulation in both normal and cancer tissues. Additionally, we aim to elucidate how MEs contribute to genetic diversity and adaptation, and their impact and potential roles in genomic instability and disease progression, especially in cancer.
Study the dynamics of gene expression and post-transcription regulation in Cancer
Our group is actively engaged in researching gene expression and alternative splicing events across various tissues, focusing on the initiation and progression of tumors. Understanding the mechanisms of gene expression control is essential for all organisms, throughout all developmental stages and under normal physiological conditions. Such control stems from the differential gene expression among various cell types, tissues, and organs within a multicellular organism. However, when this precise regulation is disrupted, it can lead to a range of pathologies, including cancer. Tumor cells often display gene expression profiles that are markedly different from those of their normal tissue counterparts. By analyzing these profiles, we can potentially classify tumors into subtypes, predict key characteristics such as aggressiveness and capacity for invasion, and anticipate the course of disease progression.
Development of web tools and databases
We are committed to advancing the field of bioinformatics through the development of innovative web tools and databases. These resources are designed to facilitate the research community's access to and analysis of complex biological data. Among our contributions are RCPedia, a comprehensive resource offering extensive annotations of retrocopies in the human genome; miRIAD, a streamlined database for investigating intragenic miRNAs; and piRNAdb, a dedicated database for PIWI-interacting RNAs (piRNAs). Our lab focuses on the intersection of computational biology and practical application, ensuring that each tool and database we develop is scientifically rigorous and user-friendly. By creating accessible, high-quality bioinformatics resources, we empower researchers worldwide to conduct their studies more efficiently and with greater precision. Please explore the capabilities of our tools and databases, and discover how they can enhance your research by visiting the respective sections on our website.
Development of Computational Tools and Algorithms
We are at the forefront of bioinformatics, developing innovative computational tools, algorithms, and pipelines to address complex biological questions. Our mission is to enhance the analysis and interpretation of genomic and transcriptomic data, thereby advancing our understanding of biological systems and diseases, particularly cancer. In developing these tools, we combine rigorous algorithmic design with cutting-edge bioinformatics techniques. Explore how our computational solutions can advance your research by visiting our 'TOOLS' section on this webpage.
Summary
Our lab investigates the impact of Mobile Elements and retrocopies on genomic variability and cancer, studies gene expression dynamics to understand tumor progression, and develops advanced bioinformatics tools and computational algorithms to enhance genomic and transcriptomic data analysis.