Search by Gene or microRNA

diablo, IAP-binding mitochondrial protein

Summary

Organism:
Official symbol:
DIABLO
Full name:
diablo, IAP-binding mitochondrial protein
Other aliases:
DFNA64 DIABLO-S SMAC SMAC3
Gene type:
protein-coding
Ensembl:
ENSG00000184047
HGNC:
21528
Entrez gene:
56616
Summary:
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Genomic context

Chromosome:
chr12
Strand:
-
Start:
122692209
End:
122712068
UCSC link:
browse this region
Gene diagram
schematic diagram of DIABLO

Intragenic microRNAs

There are no microRNAs mapped within DIABLO in our database

Gene Expression

GeneTissueGene Expression
DIABLO Cerebellum 27.08
DIABLO Heart 17.25
DIABLO Testis 78.98
DIABLO Brain 29.14
DIABLO Liver 25.93
DIABLO Kidney 47.92
  • Page 1 of 1

microRNA binding sites

The table below shows predicted conserved binding sites for DIABLO downloaded from TargetScan 6.2.

Refseq IdMature miRNASeed MatchContext Score
NM_138929 7mer-m8 -0.267
NM_019887 7mer-m8 -0.267
NM_138929 7mer-m8 -0.246
NM_019887 7mer-m8 -0.246
NM_019887 7mer-m8 -0.15
NM_138929 7mer-m8 -0.15
  • Page 1 of 1

Protein-protein interactions

ProteinPartnerOriginModeScore
DIABLO ACTA2string N/A 219.0
DIABLO ACVR1string N/A 346.0
DIABLO ACVR1Bstring N/A 226.0
DIABLO ADAstring N/A 193.0
DIABLO PARP1string N/A 609.0
DIABLO AK2string N/A 201.0
DIABLO AKT1string N/A 523.0
DIABLO AKT2string N/A 185.0
DIABLO ALBstring N/A 435.0
DIABLO ALPLstring N/A 340.0
DIABLO ALPPstring N/A 339.0
DIABLO ALPPL2string N/A 340.0
DIABLO SLC25A6string N/A 155.0
DIABLO ANXA5string N/A 428.0
DIABLO APAF1string N/A 977.0
DIABLO APEHstring N/A 196.0
DIABLO APEX1string N/A 171.0
DIABLO BIRC2hprd complex 1.0
DIABLO BIRC3hprd regular 1.0
DIABLO XIAPhprd regular 1.0