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diablo, IAP-binding mitochondrial protein

Summary

Official symbol:
DIABLO
Full name:
diablo, IAP-binding mitochondrial protein
Other aliases:
DFNA64 DIABLO-S SMAC SMAC3
Gene type:
protein-coding
Ensembl:
ENSG00000184047
HGNC:
21528
Entrez gene:
56616
Summary:
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein. [provided by RefSeq, Dec 2008]

Genomic context

Chromosome:
chr12
Strand:
-
Start:
122692209
End:
122712068
UCSC link:
browse this region
Gene diagram
schematic diagram of DIABLO

Intragenic microRNAs

There are no microRNAs mapped within DIABLO in our database

Gene Expression

GeneTissueGene Expression
DIABLO Cerebellum 1.06716
DIABLO Heart 0.435794
DIABLO Kidney 1.11872
DIABLO Liver 0.564885
DIABLO Testis 2.16158
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microRNA binding sites

The table below shows predicted conserved binding sites for DIABLO downloaded from TargetScan 6.2.

Refseq IdMature miRNASeed MatchContext Score
NM_138929 7mer-m8 -0.267
NM_019887 7mer-m8 -0.267
NM_138929 7mer-m8 -0.246
NM_019887 7mer-m8 -0.246
NM_138929 7mer-m8 -0.196
NM_138929 7mer-m8 -0.196
NM_019887 7mer-m8 -0.196
NM_019887 7mer-m8 -0.196
NM_019887 7mer-m8 -0.15
NM_138929 7mer-m8 -0.15
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Protein-protein interactions

ProteinPartnerOriginMode
DIABLO BIRC2hprd complex
DIABLO BIRC3hprd regular
DIABLO XIAPhprd regular
DIABLO BIRC5hprd regular
DIABLO CASP9hprd regular
DIABLO LTBRhprd complex
DIABLO TRAF2hprd complex
DIABLO TRAF3hprd complex
DIABLO TNFSF14hprd complex
DIABLO NGFRAP1hprd regular
DIABLO HTRA2hprd regular
DIABLO DIABLOhprd regular
DIABLO BIRC6hprd regular
DIABLO BIRC7hprd regular
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